An introduction to physical principles that govern biological matter and processes. Thermodynamic principles and their molecular origin, structural basis of life and physical and conceptual models to illustrate life phenomena. Prerequisites: Chem 6B, Math 20A, 20B, Physics 2A, 2B, 2C; majors only or consent of instructor. (W)
Laboratory practices and design principles for biotechnology. Culture of microorganisms and mammalian cells, recombinant DNA bioreactor design and operation. Design and implementation of biosensors. A team design-based term project and oral presentation required. Course material fee(s) may apply. Prerequisites: MAE 170, BIBC 102, and BENG 160; majors only or consent of department. (F)
Engineering analysis of physico-chemical rate processes that affect, limit, and govern the function of cells and tissues. Cell migration, mitosis, apoptosis, and differentiation. Dynamic and structural interactions between mesenchyme and parenchyme. The role of the tissue microenvironment including cell-cell interactions, extracellular matrix, and growth factor communication. The design of functional tissue substitutes including cell and material sourcing, scale-up and manufacturability, efficacy and safety, regulatory, and ethical topics. Clinical Applications. Prerequisites: BENG 103B or BENG 112B, senior standing or consent of department. (F)
[A]: Development of design project in tissue engineering. Prerequisites: concurrent enrollment in BENG 187B; Bioengineering or Bioengineering: Biotechnology majors only or consent of instructor. (F)
[B]:Implementation of design project in tissue engineering. Prerequisites: BENG 169A; concurrent enrollment in BENG 187C; Bioengineering or Bioengineering: Biotechnology majors only or consent of instructor. (W)
An overview of the musculoskeletal system from a bioengineering perspective. Health, injury, disease of bone, cartilage, tendon, ligament, meniscus, synovium, intervertebral disc, skeletal muscle, peripheral nerve. Mechanisms and models underlying current and future therapies. Prerequisites: departmental approval. (S)
Quantitative basic understanding of different branches of polymer science varying from polymer chemistry, characterization, thermodynamics, rheological properties, smart materials, self-assembly in biopolymers (natural) and synthetic polymers, and applications of polymers ranging from medicine to structure. Prerequisites: graduate standing in bioengineering or materials science, or consent of instructor. (W)